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Lobb M1, Norris RLG1, Charles B2, Gilshenan K3, Moore A4, Pinkerton R4 1 Australian Centre for Paediatric Pharmacokinetics, Mater Pharmacy Services, Mater Health Services, Brisbane, Australia; 2School of Pharmacy, University of Queensland, Brisbane, Australia; 3Mater Medical Research Institute, South Brisbane, Australia; 4Queensland Children's Cancer Centre, Brisbane, Australia Aims: To undertake a pharmacokinetic (PK) study of doxorubicin (dox) and its' major metabolite doxorubicinol (doxol) in paediatric patients, blood samples were drawn from the indwelling catheter through which the dosage had been administered.

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Aims: Therapeutic drug monitoring of tacrolimus in post transplant patients has been deemed to be extremely critical due to individual variability in tacrolimus pharmacokinetics (PK), which was attributed to various demographic, hematological, time-dependent (posttransplant), genetic, and ethnic factors.

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